Endocrine Abstracts

Case history: A 39 year old female had a first admission to her local hospital with cough and haemoptysis. She reported palpitations for the previous 6 months and had been previously investigated with an echocardiogram which showed a normal LV function. There was no other past medical history. During this first admission CT Pulmonary Angiogram (CTPA) demonstrated ground-glass opacifications. She was hypertensive and so a 24 hour urine sample was collected for metanephrines but...

Introduction: Adrenal masses are among the most frequent tumours in humans (ACT). A vast majority of these tumours are benign (ACAs). Only a small subset of adrenal masses are malignant adrenocortical carcinomas (ACCs). Tumour size, tumour weight, hormonal function and pathologic criteria are useful clinicopathological criteria that can result in accurate diagnosis of most ACCs and ACAs.Case report: 31-years-old woman, without relevant previous history. ...

Introduction: Low dose radioiodine (LDRAI) has been used to treat benign thyroid disease for over 70 years (1). However, controversies remain about the optimal dosage to administer. The Royal College of Physicians guidelines recommend a dosage of 400–600 MBq for uncomplicated Graves’ disease (2); the dose administered varies between centres.Methods: Outcome data at Edinburgh Royal Infirmary were collected retrospectively for patients who receiv...

Introduction: Roux-en-Y gastric bypass (RYGB) places patients at an increased risk of hypocalcemia due to the reduction in calcium absorption (because the procedure bypasses the duodenum and jejunum) and vitamin D deficiency. Subsequent thyroid surgery increases the risk of severe hypocalcemia due to potential post-operative hypoparathyroidism. Only a few cases have been published before of this kind of treatment-challenging hypocalcaemia.Case report: We...

Introduction: Agonist receptor-GLP1 (AR-GLP1) had demonstrated its utility in obese patients with diabetes type 2. Since August 2013 we have available in Spain a new AR-GLP1 with prandial action in a single daily dose, lixisenatide. There are different clinical trials that support its efficacy and security but the dates from real clinical practice are scarce.Aim: To analyse the efficacy and security in real clinical practice for the treatment of diabetic...

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of macro and microvascular disease. Previous studies suggest a link between microvascular and macrovascular complications in diabetes. However, just a few studies have investigated whether the presence of peripheral vascular disease (PVD) is associated with other macrovascular and microvascular complications in diabetes patients. So, this was the aim of our study.Patient...

Introduction: It is well known that diabetes confers a substantial burden of macrovascular disease. However, just a few studies have investigated the association between diabetic kidney disease (DKD) and cardiovascular disease. The purpose of this study is to investigate whether the presence of DKD is associated with macrovascular disease in diabetic patients.Patients and methods: 98 diabetic patients (48 males/50 females) were included in the study. DKD...

Introduction: Papillary microcarcinomas tirodieos (MCT) are tumours less than or equal to centimeter size, mostly indectectables in the clinic and found incidentally after a thyroidectomy performed for another reason, management is under discussion and its prevalence is increased ~30%, it is believed that the increased use of thyroid ultrasound.Review: 16 patients with MCT in a province of southern Spain and evaluate the clinical and prognostic variables...

Several Rab proteins control secretory granule trafficking and, hence, hormone release, by regulating the activity of different components of the secretory granule transport machinery. Particularly, Rab18 inhibits secretory granule movement, which leads to reduced neuropeptide and hormone secretion in PC12 pheochromocytoma cells and ACTH-secreting ATt20 cells, respectively, but how this GTPase accomplishes its role and the identity of the proteins that regulate Rab18 activity ...

The pituitary is an anatomically well protected endocrine gland in permanent contact with the central nervous system. Although it was known that pituitary has plasticity in response to the physiological demands of the body, there were few clear data about the post-natal mechanisms in charge of this plasticity. The discovery of a group of cells expressing stem cell markers precisely organized in the outer zone of the adenopituitary open up new possibilities to explain the const...